STRUCTURE-FUNCTION RELATIONSHIP OF PROTEINS BELONGING TO THE FAMILY OF RECEPTORS COUPLED TO GTP-BINDING PROTEINS

被引:250
作者
STROSBERG, AD [1 ]
机构
[1] INST COCHIN GENET MOLEC,PARIS,FRANCE
来源
EUROPEAN JOURNAL OF BIOCHEMISTRY | 1991年 / 196卷 / 01期
关键词
D O I
10.1111/j.1432-1033.1991.tb15778.x
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The structural properties of a number of proteins belonging to the family of receptors coupled to GTP binding proteins are discussed in relation to their function. The structure of the ligand binding site and of the regions involved in coupling to the G proteins are analyzed mainly for the adrenergic and muscarinic cholinergic receptors, for which site-directed mutagenesis and chimaeric constructions have been studied. The structure of the genes are compared and the presence of various regulatory elements is discussed in relation to control of expression. Mechanism of desensitization and internalization, while mostly studied for the beta-2-adrenergic receptor, are proposed to be generally applicable to all G-protein-coupled receptors.
引用
收藏
页码:1 / 10
页数:10
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