SIMAOMICIN (LL-D42067), A NOVEL ANTIBIOTIC FROM ACTINOMADURA-MADURAE .1. TAXONOMY, FERMENTATION AND BIOLOGICAL-ACTIVITY

被引：29

作者：

MAIESE, WM

KORSHALLA, J

GOODMAN, J

TORREY, MJ

KANTOR, S

LABEDA, DP

GREENSTEIN, M

机构：

[1] AMER CYANAMID CO,DIV AGR RES,PRINCETON,NJ 08540

[2] USDA,NRRL,CULTURE COLLECT LAB,PEORIA,IL 61604

来源：

JOURNAL OF ANTIBIOTICS | 1990年 / 43卷 / 09期

关键词：

D O I：

10.7164/antibiotics.43.1059

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A new antibacterial antibiotic, designated simaomicin α (LL-D42067 α) was isolated from the fermentation broth of an actinomycete strain. Based on cultural, physiological, morphological and chemical characteristics, culture LL-D42067 was identified as a new subspecies of Actinomadura madurae. Simaomicin α demonstrated potent activity against Gram-positive bacteria and was active in vivo against a variety of Eimeria species causing coccidiosis in chickens. © 1990, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. All rights reserved.

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页码：1059 / 1063

页数：5

相关论文

共 13 条

[1] METABOLITES OF MICROORGANISMS .162. CRYSTAL AND MOLECULAR-STRUCTURE OF LYSOLIPIN-I [J].

DOBLER, M ;

KELLERSCHIERLEIN, W .

HELVETICA CHIMICA ACTA, 1977, 60 (01) :178-185

[2] NUMERICAL TAXONOMY OF ACTINOMADURA AND RELATED ACTINOMYCETES [J].

GOODFELLOW, M ;

ALDERSON, G ;

LACEY, J .

JOURNAL OF GENERAL MICROBIOLOGY, 1979, 112 (MAY) :95-+

[3] NOCARDIA-COELIACA, NOCARDIA-AUTOTROPHICA, AND NOCARDIN STRAIN [J].

GORDON, RE ;

BARNETT, DA ;

HANDERHAN, JE ;

PANG, CHN .

INTERNATIONAL JOURNAL OF SYSTEMATIC BACTERIOLOGY, 1974, 24 (01) :54-63

[4] SOME BITS AND PIECES OF GENUS NOCARDIA - NOCARDIA-CARNEA, NOCARDIA-VACCINII, NOCARDIA-TRANSVALENSIS, NOCARDIA-ORIENTALIS AND NOCARDIA-AEROCOLONIGENES [J].

GORDON, RE ;

MISHRA, SK ;

BARNETT, DA .

JOURNAL OF GENERAL MICROBIOLOGY, 1978, 109 (NOV) :69-78

[5]

KANTOR S, 1986, 26TH INT C ANT AG CH, V223, P137

[6] ACTINOPLANONE-C, ACTINOPLANONE-D, ACTINOPLANONE-E, ACTINOPLANONE-F AND ACTINOPLANONE-G, NEW CYTO-TOXIC POLYCYCLIC XANTHONES FROM ACTINOPLANES SP [J].

KOBAYASHI, K ;

NISHINO, C ;

OHYA, J ;

SATO, S ;

MIKAWA, T ;

SHIOBARA, Y ;

KODAMA, M .

JOURNAL OF ANTIBIOTICS, 1988, 41 (06) :741-750

[7]

Lechevalier MP., 1980, ACTINOMYCETE TAXONOM, P227

[8] STRUCTURE DETERMINATION OF SIMAOMICINS ALPHA AND BETA, EXTREMELY POTENT, NOVEL ANTICOCCIDAL AGENTS PRODUCED BY ACTINOMADURA [J].

LEE, TWM ;

CARTER, GT ;

BORDERS, DB .

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1989, (22) :1771-1772

[9] LL-E19085-ALPHA, A NOVEL ANTIBIOTIC FROM MICROMONOSPORA-CITREA - TAXONOMY, FERMENTATION AND BIOLOGICAL-ACTIVITY [J].

MAIESE, WM ;

LECHEVALIER, MP ;

LECHEVALIER, HA ;

KORSHALLA, J ;

GOODMAN, J ;

WILDEY, MJ ;

KUCK, N ;

GREENSTEIN, M .

JOURNAL OF ANTIBIOTICS, 1989, 42 (06) :846-851

[10]

NONOMURA H, 1971, J FERMENT TECHNOL, V49, P904