SUBSTRATUM-GROWTH FACTOR COLLABORATIONS ARE REQUIRED FOR THE MITOGENIC ACTIVITIES OF ACTIVIN AND FGF ON EMBRYONAL CARCINOMA-CELLS

被引：60

作者：

SCHUBERT, D

KIMURA, H

机构：

[1] Salk Institute, San Diego

来源：

JOURNAL OF CELL BIOLOGY | 1991年 / 114卷 / 04期

关键词：

D O I：

10.1083/jcb.114.4.841

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

When P19 mouse embryonal carcinoma cells are grown in a serum-free N2 medium on surfaces of tissue culture plastic, they die within two days. The death of these P19 cells is prevented by activin A and basic FGF (bFGF). The cells do not divide under these conditions. However, when P19 cells are cultured on substrata of extracellular matrix proteins such as laminin and fibronectin, activin A and bFGF are potent mitogens. These data show that the substratum to which cells are exposed can regulate their mitogenic response to growth factors.

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页码：841 / 846

页数：6

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