POTENTIAL METAL-BINDING DOMAINS IN NUCLEIC-ACID BINDING-PROTEINS

被引：1071

作者：

BERG, JM

机构：

[1] Department of Biophysics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, United States

来源：

SCIENCE | 1986年 / 232卷 / 4749期

关键词：

BIOLOGICAL MATERIALS - Genes - GENETIC ENGINEERING - METALS AND ALLOYS - PROTEINS;

D O I：

10.1126/science.2421409

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A systematic search for sequences that potentially could form metal-binding domains in proteins has been performed. Five classes of proteins involved in nucleic acid binding or gene regulation were found to contain such sequences. These observations suggest numerous experiments aimed at determining whether metal-binding domains are present in these proteins and, if present, what roles such domains play in the processes of nucleic acid binding and gene regulation.

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页码：485 / 487

页数：3

相关论文

共 34 条

[1]

ADMAN E, 1975, P NATL ACAD SCI USA, V72, P4854, DOI 10.1073/pnas.72.12.4854

[2] PROTEIN DATA BANK - COMPUTER-BASED ARCHIVAL FILE FOR MACROMOLECULAR STRUCTURES [J].

BERNSTEIN, FC ;

KOETZLE, TF ;

WILLIAMS, GJB ;

MEYER, EF ;

BRICE, MD ;

RODGERS, JR ;

KENNARD, O ;

SHIMANOUCHI, T ;

TASUMI, M .

JOURNAL OF MOLECULAR BIOLOGY, 1977, 112 (03) :535-542

[3] STRUCTURAL HOMOLOGY IN THE AMINO-TERMINAL DOMAINS OF 2 AMINOACYL-TRANSFER RNA-SYNTHETASES [J].

BLOW, DM ;

BHAT, TN ;

METCALFE, A ;

RISLER, JL ;

BRUNIE, S ;

ZELWER, C .

JOURNAL OF MOLECULAR BIOLOGY, 1983, 171 (04) :571-576

[4] THE PRIMARY STRUCTURE OF TRANSCRIPTION FACTOR TFIIIA HAS 12 CONSECUTIVE REPEATS [J].

BROWN, RS ;

SANDER, C ;

ARGOS, P .

FEBS LETTERS, 1985, 186 (02) :271-274

[5] BIOCHEMICAL ACTIVITIES OF T-ANTIGEN PROTEINS ENCODED BY SIMIAN VIRUS-40-A GENE DELETION MUTANTS [J].

CLARK, R ;

PEDEN, K ;

PIPAS, JM ;

NATHANS, D ;

TJIAN, R .

MOLECULAR AND CELLULAR BIOLOGY, 1983, 3 (02) :220-228

[6] COMPLETE AMINO-ACID-SEQUENCE OF HUMAN T-CELL LEUKEMIA-VIRUS STRUCTURAL PROTEIN-P15 [J].

COPELAND, TD ;

OROSZLAN, S ;

KALYANARAMAN, VS ;

SARNGADHARAN, MG ;

GALLO, RC .

FEBS LETTERS, 1983, 162 (02) :390-395

[7] BINDING-SITES OF VIRAL PROTEIN-P19 ONTO ROUS-SARCOMA VIRUS-RNA AND POSSIBLE CONTROLS OF VIRAL FUNCTIONS [J].

DARLIX, JL ;

SPAHR, PF .

JOURNAL OF MOLECULAR BIOLOGY, 1982, 160 (02) :147-161

[8] GENE ORGANIZATION OF THE TRANSFORMING REGION OF WEAKLY ONCOGENIC ADENOVIRUS TYPE 7 - THE ELA REGION [J].

DIJKEMA, R ;

DEKKER, BMM ;

VANORMONDT, H ;

DEWAARD, A ;

MAAT, J ;

BOYER, HW .

GENE, 1980, 12 (3-4) :287-299

[9] SEQUENCE AND EXPRESSION OF HUMAN ESTROGEN-RECEPTOR COMPLEMENTARY-DNA [J].

GREENE, GL ;

GILNA, P ;

WATERFIELD, M ;

BAKER, A ;

HORT, Y ;

SHINE, J .

SCIENCE, 1986, 231 (4742) :1150-1154

[10] 2 FUNCTIONS ENCODED BY ADENOVIRUS EARLY REGION 1A ARE RESPONSIBLE FOR THE ACTIVATION AND REPRESSION OF THE DNA-BINDING PROTEIN GENE [J].

GUILFOYLE, RA ;

OSHEROFF, WP ;

ROSSINI, M .

EMBO JOURNAL, 1985, 4 (03) :707-713

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