DOMOIC ACID-INDUCED SEIZURE ACTIVITY IN RATS

被引：52

作者：

DAKSHINAMURTI, K ^{[1
]}

SHARMA, SK ^{[1
]}

SUNDARAM, M ^{[1
]}

机构：

[1] UNIV MANITOBA,FAC MED,DEPT NEUROL,WINNIPEG R3E 0W3,MANITOBA,CANADA

来源：

NEUROSCIENCE LETTERS | 1991年 / 127卷 / 02期

基金：

英国医学研究理事会;

关键词：

DOMOIC ACID; SEIZURE; GAMMA-AMINOBUTYRIC ACID; GLUTAMATE; HIPPOCAMPUS;

D O I：

10.1016/0304-3940(91)90792-R

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Domoic acid, in increasing doses (10-300 pmol), was microinjected into the hippocampal CA3 region of rats. All rats consistently exhibited generalized bilateral electrical seizure discharge activity at 100 pmol of domoic acid. Seizure latency varied inversely with the dose of domoic acid in the range tested. Local hippocampal administration of gamma-aminobutyric acid (GABA) resulted in neuronal recovery from domoic acid-induced seizures. The seizure activity of domoic acid might be the result of decreased GABAergic inhibition.

引用

页码：193 / 197

页数：5

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