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Molecular genetics of androgenic 17 beta-hydroxysteroid dehydrogenases

被引：23
作者：
Andersson, S
机构：
[1] The Cecil H. and Ida Green Center for Reproductive Biology Sciences, The University of Texas Southwestern Medical Center, Dallas, TX 75235-9051
来源：
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY | 1995年 / 55卷 / 5-6期
关键词：
D O I：
10.1016/0960-0760(95)00202-2
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
17 beta-Hydroxysteroid dehydrogenase (17 beta-HSD) type 2 catalyzes the NAD(+)-dependent oxidation of androgens, estrogens and progestins, predominantly in the secretory endometrium, placenta, liver and small intestine. 17 beta-HSD type 3 catalyzes the NADPH-dependent conversion of androstenedione to testosterone in the testis, and the genetic disease 17 beta-HSD deficiency is caused by mutations in the 17 beta-HSD3 gene.
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页码：533 / 534
页数：2
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