CD27-CD70 INTERACTION - UNRAVELING ITS IMPLICATION IN NORMAL AND NEOPLASTIC B-CELL GROWTH

被引：19

作者：

LENS, SMA

DEJONG, R

HINTZEN, RQ

KOOPMAN, G

VANLIER, RAW

VANOERS, RHJ

机构：

[1] Department of Clinical (Viro-) Immunology, Central Laboratory of the Netherlands Red Cross Blood Transfusion Service, Laboratory for Experimental and Clinical Immunology, University of Amsterdam, Amsterdam

[2] Pathology, Academic Medical Centre, Amsterdam

[3] Hematology, Academic Medical Centre, Amsterdam

来源：

LEUKEMIA & LYMPHOMA | 1995年 / 18卷 / 1-2期

关键词：

CD27; CD70; TNFR FAMILY; NORMAL B CELLS; NEOPLASTIC; B-CELL GROWTH;

D O I：

10.3109/10428199509064922

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Members of the Tumour Necrosis Factor-Receptor (TNFR) family play an essential role in the control of lymphoid cell growth and differentiation. The ligand of one of its lymphoid-specific members, CD27, was recently characterized as CD70, a type II transmembrane molecule with homology to TNF that is expressed on activated T and B cells. Ligation of CD27 by its natural ligand generates a potent costimulatory signal for cytokine production and proliferation of activated T cells. In contrast to normal B cells, where CD27 expression is confined to germinal centre cells and to a small subset of circulating B lymphocytes, CD27 expression is found on a large array of distinct B-cell neoplasia. Here, we review recent data on the expression and function of TNFR family members on normal and malignant lymphocytes and propose a role for CD27-CD70 interaction in B-cell development.

引用

页码：51 / 59

页数：9

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