EFFECTS OF CALMODULIN ANTAGONISTS ON HUMAN ADENOIDAL MAST-CELLS

被引：2

作者：

BENT, S

BRAAM, U

SCHMUTZLER, W

机构：

[1] Institut für Pharmakologic, Medizinische Fakultät der RWTH Aachen, Aachen

来源：

AGENTS AND ACTIONS | 1990年 / 30卷 / 1-2期

关键词：

D O I：

10.1007/BF01969015

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

N-(6-aminohexyl)-1-naphthalenesulfonamide (W5), N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W7) and Triflupromazine (TFPr) are substances with calmodulin antagonistic properties. All of these compounds inhibited the Con A-induced histamine release from human adenoidal mast cells. Maximal inhibition for W5 was observed at 200 μM, for W7 at 50 μM and for TFPr at 20 μM. Higher concentrations of each substance induced a marked histamine release. The kinetics of the mediator release were found to be different for Con A and W7 only after 5 mins incubation. The kinetics of TFPr were found to be biphasic: a slow onset was followed by a fast release reaction. © 1990 Birkhäuser Verlag.

引用

页码：121 / 124

页数：4

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