INHIBITION OF N-METHYL-D-ASPARTATE-INDUCED NORADRENALINE RELEASE BY ALCOHOLS IS RELATED TO THEIR HYDROPHOBICITY

被引：32

作者：

FINK, K ^{[1
]}

GOTHERT, M ^{[1
]}

机构：

[1] UNIV BONN,INST PHARMACOL & TOXICOL,REUTERSTR 2B,W-5300 BONN 1,GERMANY

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1990年 / 191卷 / 02期

关键词：

Aliphatic alcohols; Cerebral cortex (rat); Ethanol; NMDA receptors; Noradrenaline release;

D O I：

10.1016/0014-2999(90)94152-N

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

In rat brain cortex slices, ethanol was three times more potent in inhibiting [3H]noradrenaline ([3H]NA) release evoked by N-methyl-D-aspartate (NMDA) than in inhibiting the release evoked by kainic acid. Methanol, 1-propanol, 1-butanol, 1-pentanol and 1-hexanol shared the inhibitory property of ethanol on NMDA-evoked [3H]NA release. The inhibitory potency of the alcohols, as expressed by their IC50 values, was correlated with their membrane/buffer partition coefficient. It is concluded that the inhibitory effect of the alcohols may be due to a hydrophobic interaction with the NMDA receptor system. © 1990.

引用

页码：225 / 229

页数：5

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