ALTERATION OF 4 IDENTIFIED K+ CURRENTS IN DROSOPHILA MUSCLE BY MUTATIONS IN EAG

被引：116

作者：

ZHONG, Y ^{[1
]}

WU, CF ^{[1
]}

机构：

[1] UNIV IOWA, DEPT BIOL, IOWA CITY, IA 52242 USA

来源：

SCIENCE | 1991年 / 252卷 / 5012期

关键词：

D O I：

10.1126/science.2047864

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Voltage-clamp analysis of Drosophila larval muscle revealed that ether a go-go (eag) mutations affected all identified potassium currents, including those specifically eliminated by mutations in the Shaker or slowpoke gene. Together with DNA sequence analysis, the results suggest that the eag locus encodes a subunit common to different potassium channels. Thus, combinatorial assembly of polypeptides from different genes may contribute to potassium channel diversity.

引用

页码：1562 / 1564

页数：3

共 38 条

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