A PROPOSAL FOR A NEW APPROACH TO A PREVENTIVE VACCINE AGAINST HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1

被引：34

作者：

TEMIN, HM

机构：

[1] McArdle Laboratory, Madison, WI 53706

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1993年 / 90卷 / 10期

关键词：

SIMPLER RETROVIRUS; MORE COMPLEX RETROVIRUS; CO-VIRUS;

D O I：

10.1073/pnas.90.10.4419

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Human immunodeficiency virus type 1 (HIV-1) is a more complex retrovirus, coding for several accessory proteins in addition to the structural proteins (Gag, Pol, and Env) that are found in all retroviruses. More complex retroviruses have not been isolated from birds, and simpler retroviruses have not been isolated from humans. However, the proviruses of many endogenous simpler retroviruses are present in the human genome. These observations suggest that humans can mount a successful protective response against simpler retroviruses, whereas birds cannot. Thus, humans might be able to mount a successful protective response to infection with a simpler HIV-1. As a model, a simpler bovine leukemia virus which is capable of replicating has been constructed; a simpler HIV-1 could be constructed in a similar fashion. I suggest that such a simpler HIV-1 would be a safe and effective vaccine against HIV-1.

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收藏

页码：4419 / 4420

页数：2

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