SUSCEPTIBILITIES OF SEVERAL DRUG-RESISTANT HERPES-SIMPLEX VIRUS TYPE-1 STRAINS TO ALTERNATIVE ANTIVIRAL COMPOUNDS

被引：26

作者：

ANDREI, G

SNOECK, R

DECLERCQ, E

机构：

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1995年 / 39卷 / 07期

关键词：

D O I：

10.1128/AAC.39.7.1632

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Resistant herpes simplex virus type I strains were obtained under the selective pressure of acyclovir, ganciclovir, bromovinyldeoxyuridine, foscarnet, 2-phosphonylmethoxyethyl (PME) derivatives of adenine and 2,6-diaminopurine, 3-hydroxy-2-phosphonylmethoxypropyl derivatives of adenine and cytosine, and 2-amino-7-(1,3-dihydroxy-2-propoxymethyl)purine (S2242). The drug susceptibility profiles of resistant strains point to differences in the modes of action of PME and 3-hydroxy-2-phosphonylmethoxypropyl derivatives and common mechanisms of action of foscarnet, S2242, and PME derivatives against herpes simplex virus type 1 replication.

引用

收藏

页码：1632 / 1635

页数：4

相关论文

共 21 条

[1] COMPARATIVE ACTIVITY OF VARIOUS COMPOUNDS AGAINST CLINICAL STRAINS OF HERPES-SIMPLEX VIRUS [J].

ANDREI, G ;

SNOECK, R ;

GOUBAU, P ;

DESMYTER, J ;

DECLERCQ, E .

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, 1992, 11 (02) :143-151

[2]

BALZARINI J, 1991, J BIOL CHEM, V266, P8686

[3] ALTERED SENSITIVITY TO ANTIVIRAL DRUGS OF HERPES-SIMPLEX VIRUS ISOLATES FROM A PATIENT WITH THE ACQUIRED-IMMUNODEFICIENCY-SYNDROME [J].

BIRCH, CJ ;

TACHEDJIAN, G ;

DOHERTY, RR ;

HAYES, K ;

GUST, ID .

JOURNAL OF INFECTIOUS DISEASES, 1990, 162 (03) :731-734

[4] FOSCARNET - A REVIEW OF ITS ANTIVIRAL ACTIVITY, PHARMACOKINETIC PROPERTIES AND THERAPEUTIC USE IN IMMUNOCOMPROMISED PATIENTS WITH CYTOMEGALOVIRUS RETINITIS [J].

CHRISP, P ;

CLISSOLD, SP .

DRUGS, 1991, 41 (01) :104-129

[5] CHARACTERIZATION OF A DNA-POLYMERASE MUTANT OF HERPES-SIMPLEX VIRUS FROM A SEVERELY IMMUNOCOMPROMISED PATIENT RECEIVING ACYCLOVIR [J].

COLLINS, P ;

LARDER, BA ;

OLIVER, NM ;

KEMP, S ;

SMITH, IW ;

DARBY, G .

JOURNAL OF GENERAL VIROLOGY, 1989, 70 :375-382

[6]

Collins P., 1991, REV MED VIROL, V1, P19

[7] RESISTANCE TO ANTIVIRAL DRUGS OF HERPES-SIMPLEX VIRUS ISOLATED FROM A PATIENT TREATED WITH ACYCLOVIR [J].

CRUMPACKER, CS ;

SCHNIPPER, LE ;

MARLOWE, SI ;

KOWALSKY, PN ;

HERSHEY, BJ ;

LEVIN, MJ .

NEW ENGLAND JOURNAL OF MEDICINE, 1982, 306 (06) :343-346

[8] CLINICAL ISOLATE OF HERPES-SIMPLEX VIRUS TYPE-2 THAT INDUCES A THYMIDINE KINASE WITH ALTERED SUBSTRATE-SPECIFICITY [J].

ELLIS, MN ;

KELLER, PM ;

FYFE, JA ;

MARTIN, JL ;

ROONEY, JF ;

STRAUS, SE ;

LEHRMAN, SN ;

BARRY, DW .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1987, 31 (07) :1117-1125

[9]

ERLICH KS, 1989, NEW ENGL J MED, V302, P293

[10]

FOSTER SA, 1991, J BIOL CHEM, V266, P238