INTRACELLULAR CALCIUM MODULATES BASOLATERAL K+-PERMEABILITY IN FROG-SKIN EPITHELIUM

被引：9

作者：

BRODIN, B

RYTVED, KA

NIELSEN, R

机构：

[1] Laboratory of Biological Chemistry A, August Krogh Institute, University of Copenhagen, Copenhagen, DK-2100

来源：

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY | 1994年 / 426卷 / 1-2期

关键词：

K+ CHANNEL; INTRACELLULAR CALCIUM; THAPSIGARGIN; FURA-2; MICROELECTRODE -TIGHT EPITHELIUM;

D O I：

10.1007/BF00374685

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Cytosolic calcium ([Ca2+](i)) has been suggested as a key modulator in the regulation of active sodium transport across electrically ''tight'' (high resistance) epithelia. In this study we investigated the effects of calcium on cellular electrophysiological parameters in a classical model tissue, the frog skin. [Ca2+](i) was measured with fura-2 in an epifluorescence microscope setup. An inhibition of basolateral potassium permeability was observed when cytosolic calcium was increased. This inhibition was reversible upon removal of calcium from the serosal solution.

引用

页码：171 / 173

页数：3

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