FIRST CHARACTERIZATION OF INHIBITOR-RESISTANT TEM (IRT) BETA-LACTAMASES IN KLEBSIELLA-PNEUMONIAE STRAINS

被引：48

作者：

LEMOZY, J

SIROT, D

CHANAL, C

HUC, C

LABIA, R

DABERNAT, H

SIROT, J

机构：

[1] FAC MED CLERMONT FERRAND,BACTERIOL LAB,F-63001 CLERMONT FERRAND,FRANCE

[2] CHU PURPAN,MICROBIOL LAB,F-31059 TOULOUSE,FRANCE

[3] CNRS,UA 401,MUSEUM NATL HIST NAT,PARIS,FRANCE

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1995年 / 39卷 / 11期

关键词：

D O I：

10.1128/AAC.39.11.2580

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Two clinical strains of klebsiella pneumoniae, TP 01 and TP 02, presented resistance to amoxicillin-clavulanate and were fully susceptible to cephalothin. These strains produced two beta-lactamases, SHV-1 and a TEM enzyme with a pl of 5.2. The previously described changes Arg-244-->Cys and Arg-243-->Ser in IRT-1 and IRT-2 (A. Belaaouaj, C. Lapoumeroulie, M. M. Canica, G. Vedel, P. Nevot, R Krishnamoorthy, and G. Paul, FEMS Microbiol. Lett, 120:75-80, 1994) were found in TEM enzymes from the TP 01 and TP 02 strains, respectively. This is the first report of inhibitor-resistant TEM (IRT) in species other than Escherichia coli from the family Enterobacteriaceae.

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页码：2580 / 2582

页数：3

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