RECIPROCAL REGULATION OF ADIPOGENESIS BY MYC AND C/EBP-ALPHA

被引：286

作者：

FREYTAG, SO ^{[1
]}

GEDDES, TJ ^{[1
]}

机构：

[1] UNIV MICHIGAN,SCH MED,DEPT BIOL CHEM,ANN ARBOR,MI 48109

来源：

SCIENCE | 1992年 / 256卷 / 5055期

关键词：

D O I：

10.1126/science.256.5055.379

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 [理学]; 0710 [生物学]; 09 [农学];

摘要：

3T3-L1 adipoblasts that express large amounts of c-Myc cannot terminally differentiate, raising the possibility that Myc inhibits the expression of genes that promote adipogenesis. The CCAAT/enhancer binding protein (C/EBP-alpha) is induced during 3T3-L1 adipogenesis when cells commit to the differentiation pathway. Transfection of 3T3-L1 adipoblasts with the gene that encodes C/EBP-alpha caused overt expression of the adipocyte morphology. Expression of Myc prohibited the normal induction of C/EBP-alpha and prevented adipogenesis. Enforced expression of C/EBP-alpha overcame the Myc-induced block to differentiation. These results provide a molecular basis for the regulation of adipogenesis and implicate Myc and C/EBP-alpha as pivotal controlling elements.

引用

页码：379 / 382

页数：4

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