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EXTENSIVE GENETIC-POLYMORPHISM IN THE HUMAN TUMOR-NECROSIS-FACTOR REGION AND RELATION TO EXTENDED HLA HAPLOTYPES

被引：180
作者：
JONGENEEL, CV
BRIANT, L
UDALOVA, IA
SEVIN, A
NEDOSPASOV, SA
CAMBONTHOMSEN, A
机构：
[1] CHU PURPAN, INSERM, U100, F-31052 TOULOUSE, FRANCE
[2] ENGELHARDT MOLEC BIOL INST, MOSCOW, USSR
[3] CHU PURPAN, CTR RECH POLYMORPHISME GENET POPULAT HUMAINES, CNRS, UNITE PROPE RECH 8291, F-31300 TOULOUSE, FRANCE
来源：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1991年 / 88卷 / 21期
关键词：
D O I：
10.1073/pnas.88.21.9717
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
We have identified three polymorphic microsatellites (which we call TNFa, TNFb, and TNFc) within a 12-kilobase region of the human major histocompatibility complex (MHC) that includes the tumor necrosis factor (TNF) locus. TNFc is located within the first intron of the TNF-beta-gene and has only 2 alleles. TNFa and TNFb are 3.5 kilobases upstream (telomeric) of the TNF-beta-gene and have at least 13 and 7 alleles, respectively. TNFa, -b, and -c alleles are in linkage disequilibrium with alleles at other loci within the MHC, including class I, class II, and class III. TNFa, -b, and -c alleles are also associated with extended HLA haplotypes. These TNF polymorphisms will allow a thorough genetic analysis of the involvement of TNF in MHC-linked pathologies.
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页码：9717 / 9721
页数：5
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