GROWTH-HORMONE TREATMENT IN NOONAN SYNDROME - REPORT OF 4 CASES WHO REACHED FINAL HEIGHT

被引：24

作者：

MUNICCHI, G

PASQUINO, AM

PUCARELLI, I

CIANFARANI, S

PASSERI, F

机构：

[1] UNIV ROMA LA SAPIENZA,DEPT PEDIAT,PEDIAT ENDOCRINOL UNIT,I-00161 ROME,ITALY

[2] UNIV ROMA TOR VERGATA,I-00173 ROME,ITALY

来源：

HORMONE RESEARCH | 1995年 / 44卷 / 04期

关键词：

NOONAN SYNDROME; HUMAN GROWTH HORMONE; FINAL HEIGHT;

D O I：

10.1159/000184618

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Final height of 4 patients with Noonan syndrome and short stature treated with growth hormone (GH) is reported. Four prepubertal girls (chronological age 12.3-15.1 years, bone age 11.0-11.5 years) were treated with recombinant human growth hormone (0.5 IU/kg/week s.c.) for at least 3 years. Stimulated GH secretion was normal, spontaneous nocturnal GH secretion was low in 1 patient. Final height, as standard deviation score according to Ranke-specific standards for Noonan syndrome, improved in 3 patients and 2 of them exceeded their corrected midparental height.

引用

页码：164 / 167

页数：4

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