PHARMACOKINETICS AND TOXIC EFFECTS OF NIFEDIPINE IN MASSIVE OVERDOSE

被引：15

作者：

FERNER, RE ^{[1
]}

MONKMAN, S ^{[1
]}

RILEY, J ^{[1
]}

CHOLERTON, S ^{[1
]}

IDLE, JR ^{[1
]}

BATEMAN, DN ^{[1
]}

机构：

[1] UNIV NEWCASTLE UPON TYNE, DEPT PHARMACOL,PHARMACOGENET RES UNIT, NEWCASTLE UPON TYNE NE2 4HH, ENGLAND

来源：

HUMAN & EXPERIMENTAL TOXICOLOGY | 1990年 / 9卷 / 05期

关键词：

D O I：

10.1177/096032719000900507

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

A 57-year-old man took 30 × 20 mg nifedipine retarded release tablets. He developed hypotension, tachycardia and flushing, but remained in sinus rhythm. The concentration of nifedipine 10 h after overdose was 604 μg 1-1, and of the M-I metabolite 110 μg 1-1. Log concentration time curves were linear from 10-72 h for nifedipine, with a half-life of 7.5 h; and for M-I with a half-life of 8.2 h. On this evidence, oral absorption of nifedipine retarded release is complete by 10 h. There was no evidence of saturation of nifedipine or M-I metabolism, even at concentrations ten times above the therapeutic concentration. © 1990, Sage Publications. All rights reserved.

引用

页码：309 / 311

页数：3

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