Paraherquamides B (2, C27H33N3O4), C (3, C28H33N3O4), D (4, C28H33 N3O5), E (5, C28H35N3O4), F (6, C28H35N3O3), AND G (7, C28H35N3O4) are novel metabolites of Penicillium charlesii. The structures of these compounds have been determined by NMR and MS analysis.