SYNTHESIS AND BINDING-PROPERTIES OF MONOMERIC AND DIMERIC GUANINE AND CYTOSINE AMINE DERIVATIVES

被引：43

作者：

SESSLER, JL

MAGDA, D

FURUTA, H

机构：

[1] Department of Chemistry and Biochemistry, University of Texas, Austin

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1992年 / 57卷 / 03期

关键词：

D O I：

10.1021/jo00029a008

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The syntheses of the N-protected forms of the cytosine homodimer 1, the guanine cytosine heterodimer 2, and the guanine homodimer 3 are described. Derivatization of these dimers, as well as the protected monomers corresponding to 4 and 5, with omega-methoxypoly(ethylene glycol)-alpha-carboxylic acid 26 and subsequent deprotection formed the amides 29, 31, 33, 35, and 37. The binding properties of these solubilized compounds in DMSO-d(g) were examined using H-1 NMR.

引用

页码：818 / 826

页数：9

共 18 条

[1]

BROOKES P, 1961, J CHEM SOC, P3623

[2]

CONNORS KA, 1987, BINDING CONSTANTS, pCH5

[3] A REGIOCONTROLLED SYNTHESIS OF N7-GUANINE AND N9-GUANINE NUCLEOSIDES [J].