THE DIAGNOSTIC-VALUE OF SALIVARY FLUID LEVELS OF BETA-2-MICROGLOBULIN, LYSOZYME AND LACTOFERRIN FOR PRIMARY SJOGRENS-SYNDROME

被引：11

作者：

MARKUSSE, HM

OTTEN, HG

VROOM, TM

SMEETS, TJM

FOKKENS, N

BREEDVELD, FC

机构：

[1] Department of Rheumatology, Dr. Daniël Den Hoed Clinic, Rotterdam, 3008 AE

[2] Department of Rheumatology, University Hospital Leiden

[3] Department of Pathology, Dr. Daniël Den Hoed Clinic, Rotterdam, 3008 AE

[4] Department of Dentistry, Dr. Daniël Den Hoed Clinic, Rotterdam, 3008 AE

来源：

CLINICAL RHEUMATOLOGY | 1992年 / 11卷 / 04期

关键词：

BETA-MICROGLOBULIN; LYSOZYME; LACTOFERRIN; SALIVA; SJORGRENS SYNDROME;

D O I：

10.1007/BF02283111

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In search of a simple non-invasive diagnostic test for primary Sjogren's syndrome (SS) the concentration of beta2-microglobulin (beta2-m), lysozyme (LZM) and lactoferrin (Lf) was measured in stimulated parotid saliva of 39 patients with primary SS, 42 patients suspected of the syndrome in whom the diagnosis could be excluded (NON-SS) and in 41 normal control individuals. Salivary fluid levels of beta2-m, LZM and Lf exceeding the mean + 2 X standard deviation of healthy control values were found in respectively 58%, 23%, and 26% of the primary SS patients and in 7%, 11% and 0% of the NON-SS patients. The results of this study indicate that due to the low sensitivity the tests are not suitable as a screening procedure for patients suspected of having primary SS. However, measurement of beta2-m in stimulated parotid saliva may be used as an adjunctive diagnostic test for primary SS.

引用

页码：521 / 525

页数：5

共 31 条

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