STRUCTURE OF THE GENE ENCODING THE MOUSE PITUITARY ADENYLATE CYCLASE-ACTIVATING POLYPEPTIDE RECEPTOR

被引：46

作者：

AINO, H

HASHIMOTO, H

OGAWA, N

NISHINO, A

YAMAMOTO, K

NOGI, H

NAGATA, S

BABA, A

机构：

[1] OSAKA UNIV,FAC PHARMACEUT SCI,DEPT PHARMACOL,SUITA,OSAKA 565,JAPAN

[2] OSAKA BIOSCI INST,SUITA,OSAKA 565,JAPAN

来源：

GENE | 1995年 / 164卷 / 02期

关键词：

PACAP; VIP; GENOMIC ORGANIZATION; ALTERNATIVE SPLICING; 5'-FLANKING REGION; AMINO-ACID SEQUENCE;

D O I：

10.1016/0378-1119(95)00391-I

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The PACAP-R gene, encoding the mouse pituitary adenylate cyclase-activating polypeptide receptor (PACAP-R), has been isolated and its structural organization has been determined. PACAP-R spans more than 50 kb and is divided into 18 exons. PACAP-R contains two alternative exons encoding the putative third intracellular loop, as found in the rat PACAP-R. The proximal promoter region is highly G+C rich and lacks an apparent TATA box, but contains a CCAAT box and two potential Spl-binding sites.

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页码：301 / 304

页数：4

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