EPIDEMIOLOGY OF INVASIVE HAEMOPHILUS-INFLUENZAE INFECTIONS IN ENGLAND AND WALES IN THE PRE-VACCINATION ERA (1990-2)

被引：37

作者：

ANDERSON, EC

BEGG, NT

CRAWSHAW, SC

HARGREAVES, RM

HOWARD, AJ

SLACK, MPE

机构：

[1] OXFORD RADCLIFFE HOSP,OXFORD PUBL HLTH LAB,OXFORD OX3 9DU,ENGLAND

[2] PUBL HLTH LAB SERV,CTR COMMUNICABLE DIS SURVEILLANCE,LONDON NW9 5EQ,ENGLAND

[3] GWYNNEDD HOSP,BANGOR,GWYNEDD,WALES

来源：

EPIDEMIOLOGY AND INFECTION | 1995年 / 115卷 / 01期

关键词：

D O I：

10.1017/S0950268800058155

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

This survey defined the pattern of invasive Haemophilus influenzae infections during 1990-2 in six regions in England and Wales during the pre-vaccination era providing a baseline against which any changes in patterns of disease due to the introduction of the Haemophilus influenzae type b vaccination programme can be monitored. A total of 946 cases of invasive Haemophilus influenzae were recorded during the survey period of which almost 90% were due to type b and most of the remainder were non-typeable. Type b infections occurred predominantly in children less than 5 years of age (88%) with the highest attack rate in male infants in the 6-11 month age group. Diagnostic category varied with both age and serotype; meningitis was the commonest presentation overall but pneumonia and bacteraemia were more common in adults and non-typeable isolates. Mortality was highest in neonates and the elderly (over 65 years of age) who were more likely to have an underlying predisposing condition than older children and adults. Children under 5 years of age had a higher case fatality rate for non-typeable than for type b infections. Ampicillin resistance was 15% and there were no cefotaxime resistant type b isolates.

引用

页码：89 / 100

页数：12

共 16 条

[1]

Makela P.H., Takala A.K., Peltola H., Eskola J., Epidemiology of invasive Haemophilus influenzae type b disease, J Infect Dis, 165, 1, (1992)

[2]

Booy R., Hodgson S.A., Slack M., Invasive Haemophilus influenzae type b disease in the Oxford Region (1985–1991), Arch Dis Child, 69, pp. 225-228, (1993)

[3]

Howard A.J., Dunkin K.T., Muser J.M., Epidemiology of Haemophilus influenzae type b invasive disease: Wales, BMJ, 303, pp. 441-445, (1991)

[4]

Wallace R.J., Muser D.M., Septimus E.J., Haemophilus influenzae infections in adults: characterisation of strains by serotypes, biotypes and β-lactamase production, J Infect Dis, 144, pp. 101-106, (1981)

[5]

Slack M., Crook D., Jordens J.Z., Molecular and epidemiological aspects of Haemophilus influenzae infection, PHLS Micro Digest, 10, pp. 122-128, (1993)

[6]

Peltola H., Rod T.O., Jonsdottir K., Life-threatening Haemophilus influenzae infections in Scandinavia: A five country analysis of the incidence and the main clinical and bacteriological characteristics, Rev Infect Dis, 12, (1990)

[7]

Broome C.V., Epidemiology of Haemophilus influenzae type b infections in the United States, Pediatr Infect Dis J, 6, (1987)

[8]

Gilbert G.L., Clements D.A., Broughton S.J., Haemophilus influenzae type b infections in Victoria, Australia 1985–1987, Pediatr Infect Dis J, 9, pp. 252-257, (1990)

[9]

Hanna J.N., The epidemiology of invasive Haemophilus influenzae infections in children under five vears of age in the Northern Territory: a three year study, Med J Aust, 152, pp. 234-240, (1990)

[10]

Biljmer H.A., van Alphen L., Greenwood B.M., The epidemiology of Haemophilus influenzae meningitis in children under five years of age in the Gambia, West Africa, J Infect Dis, 161, pp. 1210-1215, (1990)

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