COMBINED GONADOTROPIN-RELEASING-HORMONE AGONIST HUMAN MENOPAUSAL GONADOTROPIN THERAPY (GNRH-A/HMG) IN NORMAL, HIGH, AND POOR RESPONDERS TO HMG

被引：25

作者：

BENRAFAEL, Z

BIDER, D

DAN, U

ZOLTI, M

LEVRAN, D

MASHIACH, S

机构：

[1] Department of Obstetrics and Gynecology, The Chaim Sheba Medical Center, Tel Hashomer

[2] Sackler School of Medicine, Tel Aviv University, Tel Hashomer

来源：

JOURNAL OF IN VITRO FERTILIZATION AND EMBRYO TRANSFER | 1991年 / 8卷 / 01期

关键词：

GONADOTROPIN RELEASING HORMONE (GNRH) ANALOG; HUMAN MENOPAUSAL GONADOTROPIN (HMG); PATIENT RESPONSE;

D O I：

10.1007/BF01131588

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Patients who failed to conceive after gonadotropin stimulation in in vitro fertilization treatment were classified into normal, high, or poor responders. They were routinely offered another cycle with a combination of a gonadotropin releasing hormone agonist and gonadotropin therapy (in order to evaluate whether this combined therapy could improve their response). The gonadotropin-induced cycle was compared with the combined therapy cycle. With the combination treatment, in the normal responders the phase of ovarian stimulation was significantly (P < 0.001) prolonged, and the number of follicles and oocytes collected (5.7 +/- 0.7 vs 3.1 +/- 0.4) was increased, without any change in serum estradiol level compared to the control cycle. In high responders the number of oocytes was not modified by the combined treatment compared with the control cycle. However, serum estradiol level was significantly (P < 0.005) decreased. The combined therapy did not modify any parameter of response in poor responders. We conclude that the response to combined agonist/gonadotropin therapy is dependent on the patient's own basal response. No improvement in response was expected in poor responders.

引用

页码：33 / 36

页数：4

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