MEMORY IMPAIRMENT AND MORPHOLOGICAL-CHANGES IN RATS INDUCED BY ACTIVE FRAGMENT OF ANTI-NERVE GROWTH FACTOR-ANTIBODY

被引：25

作者：

NABESHIMA, T

OGAWA, S

ISHIMARU, H

KAMEYAMA, T

FUKUTA, T

TAKEUCHI, R

HAYASHI, K

机构：

[1] NAGOYA UNIV,SCH MED,DEPT HOSP PHARM,NAGOYA,AICHI 466,JAPAN

[2] EISAI & CO LTD,DRUG SAFETY RES CTR,GIFU 483,JAPAN

[3] GIFU COLL PHARM,DEPT PHARMACEUT,GIFU 502,JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1991年 / 175卷 / 01期

关键词：

D O I：

10.1016/S0006-291X(05)81222-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Treatment of rats with a specific Fab' fragment of anti-nerve growth factor (NGF)-antibody (anti-NGF, 12, 120 and 400 μg/4 weeks, i.c.v.) impaired their learning ability. The distance of swimming of anti-NGF treated rats in a water maze was shortened more slowly by training than that of control rats. Anti-NGF treatment altered the staining of nuclei of cells in the hippocampus, parietal cortex and dentate gyrus with hematoxylin. It is suggested that the anti-NGF-induced amnesia could be due to change in nuclear morphology. © 1991 Academic Press, Inc.

引用

页码：215 / 219

页数：5

共 16 条

[1] AMELIORATION OF CHOLINERGIC NEURON ATROPHY AND SPATIAL MEMORY IMPAIRMENT IN AGED RATS BY NERVE GROWTH-FACTOR [J].