SUPPRESSING EFFECTS OF GLUCAN ON MICRONUCLEI INDUCED BY CYCLOPHOSPHAMIDE IN MICE

被引：24

作者：

CHORVATOVICOVA, D ^{[1
]}

NAVAROVA, J ^{[1
]}

机构：

[1] SLOVAK ACAD SCI, INST EXPTL PHARMACOL, CS-80936 BRATISLAVA, CZECHOSLOVAKIA

来源：

MUTATION RESEARCH | 1992年 / 282卷 / 03期

关键词：

CARBOXYMETHYLGLUCAN; CYCLOPHOSPHAMIDE; ANTIMUTAGENICITY; MICRONUCLEUS TEST; (MICE);

D O I：

10.1016/0165-7992(92)90088-Y

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The effect of pretreatment with carboxymethylglucan (CMG) on the frequency of micronuclei induced by cyclophosphamide administration in mice was evaluated. Two doses of CMG (50 mg/kg body weight) injected either intraperitoneally 24 h or intravenously 1 h prior to two cyclophosphamide administrations (80 mg/kg) significantly decreased the frequency of micronucleated PCE in bone marrow. Of two evaluated derivatives of carboxymethylglucan, the K3 derivative was most efficient. The results show that it is possible to achieve a suppressive effect of Soluble carboxymethylglucan prepared from Saccharomyces cerevisiae against cyclophosphamide mutagenicity. The notion may be useful for glucan's effects against pharmacocarcinogenesis. Therapeutic application of glucan with cyclophosphamide therapy may provide a remarkable decrease of the secondary tumour risk. The utilization of these results for human patients needs to be considered.

引用

页码：147 / 150

页数：4

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