PLATELET INTRACELLULAR CALCIUM IN PATIENTS WITH RECURRENT AFFECTIVE-DISORDERS

被引:23
作者
BOTHWELL, RA
ECCLESTON, D
MARSHALL, E
机构
[1] University Department of Psychiatry, Leazes Wing, Royal Victoria Infirmary, Newcastle upon Tyne, NE1 4LP, Queen Victoria Road
关键词
RECURRENT AFFECTIVE; DISORDER; PLATELETS; INTRACELLULAR RESTING CALCIUM; SEROTONIN; THROMBIN; PLATELET ACTIVATING FACTOR; LITHIUM; SERUM CALCIUM;
D O I
10.1007/BF02244862
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Forty-four subjects with a history of a major recurrent affective disorder in remission and who were either on no medication or taking a single dose of psychotropic medication were conscripted together with matched controls. The fluorescent indicator fura 2 was used to measure intracellular calcium in platelets and estimations were made of total serum and ionised calcium as well as of whole blood serotonin. Intracellular calcium was measured in the resting state as well as after stimulation with thrombin, platelet activating factor and serotonin. No significant differences were found between the 17 subjects with a diagnosis of bipolar disorder or the 27 subjects with recurrent unipolar depression and their matched controls. Intracellular calcium measures were significantly higher in the lithium treated group after stimulation with 5HT, whereas the subjects taking tricyclic antidepressants did not differ significantly from their controls on any measure. Serum calcium was found to be significantly higher in those subjects taking lithium. These findings suggest that the measurement of intracellular calcium is not a useful trait marker in affective disorders. Lithium appears to enhance the 5HT induced rise of intracellular calcium.
引用
收藏
页码:375 / 381
页数:7
相关论文
共 67 条
[1]   C-KINASE ACTIVATION PROLONGS CA-2+-DEPENDENT INACTIVATION OF K+ CURRENTS [J].
ALKON, DL ;
KUBOTA, M ;
NEARY, JT ;
NAITO, S ;
COULTER, D ;
RASMUSSEN, H .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1986, 134 (03) :1245-1253
[2]   DIFFERENTIAL-EFFECTS OF LITHIUM ON MUSCARINIC RECEPTOR STIMULATION OF INOSITOL PHOSPHATES IN RAT CEREBRAL-CORTEX SLICES [J].
BATTY, I ;
NAHORSKI, SR .
JOURNAL OF NEUROCHEMISTRY, 1985, 45 (05) :1514-1521
[3]   AN INVENTORY FOR MEASURING DEPRESSION [J].
BECK, AT ;
ERBAUGH, J ;
WARD, CH ;
MOCK, J ;
MENDELSOHN, M .
ARCHIVES OF GENERAL PSYCHIATRY, 1961, 4 (06) :561-&
[4]   INOSITOL TRISPHOSPHATE AND DIACYLGLYCEROL AS 2ND MESSENGERS [J].
BERRIDGE, MJ .
BIOCHEMICAL JOURNAL, 1984, 220 (02) :345-360
[5]   NEURAL AND DEVELOPMENTAL ACTIONS OF LITHIUM - A UNIFYING HYPOTHESIS [J].
BERRIDGE, MJ ;
DOWNES, CP ;
HANLEY, MR .
CELL, 1989, 59 (03) :411-419
[6]   LITHIUM AMPLIFIES AGONIST-DEPENDENT PHOSPHATIDYLINOSITOL RESPONSES IN BRAIN AND SALIVARY-GLANDS [J].
BERRIDGE, MJ ;
DOWNES, CP ;
HANLEY, MR .
BIOCHEMICAL JOURNAL, 1982, 206 (03) :587-595
[7]   ELECTROLYTES IN BLOOD IN ENDOGENOUS DEPRESSION [J].
BJORUM, N .
ACTA PSYCHIATRICA SCANDINAVICA, 1972, 48 (01) :59-&
[8]   ELECTROLYTES IN CEREBROSPINAL-FLUID IN ENDOGENOUS DEPRESSION [J].
BJORUM, N ;
PLENGE, P ;
RAFAELSE.OJ .
ACTA PSYCHIATRICA SCANDINAVICA, 1972, 48 (06) :533-539
[9]   LONG-TERM EFFECT OF LITHIUM ON THE UPTAKE OF 5-HYDROXYTRYPTAMINE BY HUMAN-PLATELETS [J].
BORN, GVR ;
GRIGNANI, G ;
MARTIN, K .
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 1980, 9 (04) :321-325
[10]   CALCIUM FUNCTION IN AFFECTIVE-DISORDERS AND HEALTHY CONTROLS [J].
BOWDEN, CL ;
HUANG, LG ;
JAVORS, MA ;
JOHNSON, JM ;
SELESHI, E ;
MCINTYRE, K ;
CONTRERAS, S ;
MAAS, JW .
BIOLOGICAL PSYCHIATRY, 1988, 23 (04) :367-376