BCL-2 OVEREXPRESSION ABOLISHES EARLY CALCIUM WAVING PRECEDING APOPTOSIS IN NIH-3T3 MURINE FIBROBLASTS

被引：45

作者：

MAGNELLI, L ^{[1
]}

CINELLI, M ^{[1
]}

TURCHETTI, A ^{[1
]}

CHIARUGI, VP ^{[1
]}

机构：

[1] UNIV FLORENCE,INST GEN PATHOL,MOLEC BIOL LAB,I-50134 FLORENCE,ITALY

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1994年 / 204卷 / 01期

关键词：

D O I：

10.1006/bbrc.1994.2429

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Overexpression of the apoptosis protection gene bcl-2 abolished the earliest response to serum withdrawal in NIH-3T3 murine fibroblasts, i.e., the abrupt cytoplasmic free calcium drop. This phenomenon, also observed in a myeloid cell line, led us to propose this ionic waving as an early apoptotic signal. Its abolition by bcl-2 overexpression suggests that this gene plays a role also on early events ''priming'' apoptosis. (C) Academic Press, Inc.

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页码：84 / 90

页数：7

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