TRANSLATION OF RNAIII, THE STAPHYLOCOCCUS-AUREUS AGR REGULATORY RNA MOLECULE, CAN BE ACTIVATED BY A 3'-END DELETION

被引:30
作者
BALABAN, N [1 ]
NOVICK, RP [1 ]
机构
[1] NYU, MED CTR, SKIRBALL INST, NEW YORK, NY 10016 USA
关键词
STAPHYLOCOCCUS AUREUS; AGR; BACTERIAL VIRULENCE; GLOBAL REGULON; RNAIII;
D O I
10.1111/j.1574-6968.1995.tb07877.x
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
RNAIII, an RNA molecule shown to encode delta-hemolysin and independently to regulate toxin synthesis in Staphylococcus aureus, is transcribed at the mid-exponential phase of growth, while its target genes are activated 2 h later, at the post-exponential phase of growth. We show here that the translation of RNAIII to the 26-amino acid peptide delta-hemolysin is delayed by 1 h, and that this delay is abolished when the 3'-end of this molecule is deleted, We suggest that structural changes of RNAIII to a translatable form of the molecule precede its regulation of target gene expression.
引用
收藏
页码:155 / 161
页数:7
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