LACK OF RESPONSIVENESS TO GLUCOSE OF MICROENCAPSULATED ISLETS OF LANGERHANS AFTER 3 WEEKS IMPLANTATION IN THE RAT INFLUENCE OF THE COMPLEMENT

被引：22

作者：

GIN, H ^{[1
]}

DUPUY, B ^{[1
]}

BAQUEY, A ^{[1
]}

BAQUEY, C ^{[1
]}

DUCASSOU, D ^{[1
]}

机构：

[1] UNIV BORDEAUX 2,INSERM,U306,146 RUE LEO SAIGNAT,ZONE N,BATIMENT 4,F-33076 BORDEAUX,FRANCE

来源：

JOURNAL OF MICROENCAPSULATION | 1990年 / 7卷 / 03期

关键词：

D O I：

10.3109/02652049009021844

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Microencapsulated islets of Langerhans retrieved from peritoneal cavity of rats three weeks after implantation had a reduced hormonal secretion and were no longer responsive to alterations in glucose levels. Activation of complement could not completely account for the observed fibrosis which was thought to be responsible for the loss of responsiveness of the encapsulated cells. © 1990 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

引用

页码：341 / 346

页数：6

共 19 条

[1]

Altman J.J., Houlbert D., Callard P., McMillan P., Solomon B.A., Rosen J., Galletti P.M., Long-term plasma glucose normalization in experimental diabetic rats with macroencapsulated implants of benign human insulinomas, Diabetes, 35, pp. 625-633, (1986)

[2]

Boag A.H., Sefton M.V., Microencapsulating of human fibroblasts in a water-insoluble polyacrylate, Biotechnology and Bioengineering, 30, pp. 954-962, (1987)

[3]

Braun K., Kuttler B., Jahr H., Hahn H.J., Prevention of complement mediated cytotoxicity against rat islets by encapsulation in a cellulose sulphate membrane, Hormone and Metabolism Research, 19, pp. 345-347, (1987)

[4]

Cheung A.K., Parker C.J., Jamatova J., Analysis of the complement C3 fragments associated with hemodialysis membranes, Kidney International, 35, pp. 576-588, (1989)

[5]

Chicheportiche D., Reach G., Kinetics of insulin release by microencapsulated islets: effect of the size of the microcapsule, Diabetologia, 31, pp. 54-57, (1988)

[6]

Dupuy B., Gin H., Baquey C., Ducassou D., In Situ polymerization of a microencapsulating medium round living cells, Journal of Biomedical Materials Research, 22, pp. 1061-1070, (1988)

[7]

Fu X.W., Sun A.M., Microencapsulated parathyroid cells as a bioartificial parathyroid, Transplantation, 47, pp. 432-435, (1989)

[8]

Gin H., Dupuy B., Baquey C., Ducassou D., Préservation de l'intégrité fonctionnelle d'un matériel cellulaire après enrobage par polymérisation, Comptes Rendus de la Société de Biologie, 182, pp. 79-85, (1988)

[9]

Gin H., Dupuy B., Bonnemaison-Bourignon D., Bordenave L., Bareille R., Latapie M.J., Bezian J.H., Ducassou D., Biocompatibility of polyacrylamide microcapsules implanted in peritoneal cavity or spleen of the rat. Effect on various inflammatory reactions in vitro, Biomaterials, Artificial Cells, and Artificial Organs, 18, pp. 1-10, (1990)

[10]

Gin H., Dupuy B., Caix J., Baquey C., Ducassou D., In Vitro diffusion in polyacrylamide embedded agarose microbeads, Journal of Microencapsulation, 7, pp. 17-23, (1990)

← 1 2 →