PRINCIPLES OF SELECTIVE INACTIVATION OF VIRAL GENOME .6. INACTIVATION OF THE INFECTIVITY OF THE INFLUENZA-VIRUS BY THE ACTION OF BETA-PROPIOLACTONE

被引：32

作者：

BUDOWSKY, EI ^{[1
]}

FRIEDMAN, EA ^{[1
]}

ZHELEZNOVA, NV ^{[1
]}

NOSKOV, FS ^{[1
]}

机构：

[1] MINIST PUBL HLTH USSR,INST EPIDEMIOL & MICROBIOL,LENINGRAD,USSR

来源：

VACCINE | 1991年 / 9卷 / 06期

关键词：

VIRUSES; INFLUENZA; INACTIVATION KINETICS; BETA-PROPIOLACTONE;

D O I：

10.1016/0264-410X(91)90125-P

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The kinetics of inactivation of the infectivity of the influenza virus by beta-propiolactone have been studied. Rate constants have been determined for inactivation of the A/Leningrad/385 (H3N2) and B/Leningrad/489/80 influenza virus under the action of beta-propiolactone on a virus-containing allantoic fluid and a purified viral suspension. The data obtained allow calculation of the time required for inactivation of the influenza virus infectivity to a given extent in virus-containing solutions at any initial concentration of beta-propiolactone.

引用

页码：398 / 402

页数：5

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