TUNGSTEN TREATMENT PREVENTS TUMOR NECROSIS FACTOR-INDUCED INJURY OF BRAIN ENDOTHELIAL-CELLS

被引：23

作者：

TERADA, LS

WILLINGHAM, IR

GUIDOT, DM

SHIBAO, GN

KINDT, GW

REPINE, JE

机构：

[1] UNIV COLORADO,HLTH SCI CTR,DEPT MED,DENVER,CO 80262

[2] UNIV COLORADO,HLTH SCI CTR,DEPT NEUROSURG,DENVER,CO 80262

来源：

INFLAMMATION | 1992年 / 16卷 / 01期

关键词：

D O I：

10.1007/BF00917511

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Exposure to recombinant human tumor necrosis factor-alpha (TNF-alpha) or calcium ionophore (A23187) for 4 h increased (P < 0.05) lactate dehydrogenase (LDH) release from cultured bovine brain endothelial cells (EC). In contrast, treatment with endotoxin or interleukin-1 did not increase (P > 0.05) LDH release from brain EC. Pretreatment with tungsten decreased (P < 0.05) xanthine oxidase activity in brain EC and decreased (P < 0.05) LDH release from brain EC following exposure to TNF. Our results suggest that TNF-alpha injures brain microvascular EC and that this effect may be mediated by xanthine oxidase.

引用

页码：13 / 19

页数：7

共 27 条

[1] ROLE OF XANTHINE-OXIDASE AND NEUTROPHILS IN ISCHEMIA-REPERFUSION INJURY IN RABBIT LUNG
ADKINS, WK
TAYLOR, AE
[J]. JOURNAL OF APPLIED PHYSIOLOGY, 1990, 69 (06) : 2012 - 2018
[2] HYPEROXIA DAMAGES CULTURED ENDOTHELIAL-CELLS CAUSING INCREASED NEUTROPHIL ADHERENCE
BOWMAN, CM
BUTLER, EN
REPINE, JE
[J]. AMERICAN REVIEW OF RESPIRATORY DISEASE, 1983, 128 (03): : 469 - 472
[3] BRAIN MICROVESSEL ENDOTHELIAL-CELLS IN TISSUE-CULTURE - A MODEL FOR STUDY OF BLOOD-BRAIN-BARRIER PERMEABILITY
BOWMAN, PD
ENNIS, SR
RAREY, KE
BETZ, AL
GOLDSTEIN, GW
[J]. ANNALS OF NEUROLOGY, 1983, 14 (04) : 396 - 402
[4] TUMOR NECROSIS FACTOR CACHECTIN INCREASES PERMEABILITY OF ENDOTHELIAL-CELL MONOLAYERS BY A MECHANISM INVOLVING REGULATORY G-PROTEINS
BRETT, J
GERLACH, H
NAWROTH, P
STEINBERG, S
GODMAN, G
STERN, D
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1989, 169 (06) : 1977 - 1991
[5] ANTIOXIDANTS PROTECT CULTURED BOVINE LUNG ENDOTHELIAL-CELLS FROM INJURY BY ENDOTOXIN
BRIGHAM, KL
MEYRICK, B
BERRY, LC
REPINE, JE
[J]. JOURNAL OF APPLIED PHYSIOLOGY, 1987, 63 (02) : 840 - 850
[6] INTERLEUKIN-1 PRETREATMENT DECREASES ISCHEMIA REPERFUSION INJURY
BROWN, JM
WHITE, CW
TERADA, LS
GROSSO, MA
SHANLEY, PF
MULVIN, DW
BANERJEE, A
WHITMAN, GJR
HARKEN, AH
REPINE, JE
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (13) : 5026 - 5030
[7] XANTHINE-OXIDASE PRODUCES HYDROGEN-PEROXIDE WHICH CONTRIBUTES TO REPERFUSION INJURY OF ISCHEMIC, ISOLATED, PERFUSED RAT HEARTS
BROWN, JM
TERADA, LS
GROSSO, MA
WHITMANN, GJ
VELASCO, SE
PATT, A
HARKEN, AH
REPINE, JE
[J]. JOURNAL OF CLINICAL INVESTIGATION, 1988, 81 (04) : 1297 - 1301
[8] MEDIATOR-INDUCED ACTIVATION OF XANTHINE-OXIDASE IN ENDOTHELIAL-CELLS
FRIEDL, HP
TILL, GO
RYAN, US
WARD, PA
[J]. FASEB JOURNAL, 1989, 3 (13) : 2512 - 2518
[9] TUMOR-NECROSIS-FACTOR (CACHECTIN) AS AN ESSENTIAL MEDIATOR IN MURINE CEREBRAL MALARIA
GRAU, GE
FAJARDO, LF
PIGUET, PF
ALLET, B
LAMBERT, PH
VASSALLI, P
[J]. SCIENCE, 1987, 237 (4819) : 1210 - 1212
[10] TUMOR NECROSIS FACTOR IDENTIFIED IN MULTIPLE-SCLEROSIS BRAIN
HOFMAN, FM
HINTON, DR
JOHNSON, K
MERRILL, JE
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1989, 170 (02) : 607 - 612

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