THE ROLE OF PENICILLIN-BINDING PROTEIN-3 (PBP-3) IN CEFOTAXIME RESISTANCE IN STREPTOCOCCUS-PNEUMONIAE

被引：12

作者：

SELAKOVITCHCHENU, L ^{[1
]}

SEROUDE, L ^{[1
]}

SICARD, AM ^{[1
]}

机构：

[1] CNRS,MICROBIOL & GENET MOLEC LAB,118 ROUTE NARBONNE,F-31062 TOULOUSE,FRANCE

来源：

MOLECULAR & GENERAL GENETICS | 1993年 / 239卷 / 1-2期

关键词：

PENICILLIN-BINDING PROTEINS; STREPTOCOCCUS-PNEUMONIAE; BETA-LACTAMS; PEPTIDOGLYCAN;

D O I：

10.1007/BF00281604

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A pneumococcal strain, with a reduced amount of penicillin-binding protein 3 (PBP 3), permitted an analysis of the role of this protein in cefotaxime resistance. We observed that reduced amounts of PBP 3 sensitize the bacteria to high temperature, to excess glycine and to some D-amino acids. These phenotypes suggest that the amount of PBP 3 may influence the membrane properties of the bacteria. The strain with reduced PBP 3 was transformed to cefotaxime resistance. We show that the PBP 3 mutation, in certain genetic backgrounds, decreases the level of resistance to cefotaxime by a factor of 2. Models are presented to explain this result.

引用

页码：77 / 80

页数：4

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