INCREASE IN PERIPHERAL NATURAL-KILLER-CELL ACTIVITY IN PATIENTS WITH AUTOIMMUNE THYROID-DISEASE

被引：50

作者：

HIDAKA, Y ^{[1
]}

AMINO, N ^{[1
]}

IWATANI, Y ^{[1
]}

KANEDA, T ^{[1
]}

NASU, M ^{[1
]}

MITSUDA, N ^{[1
]}

TANIZAWA, O ^{[1
]}

MIYAI, K ^{[1
]}

机构：

[1] OSAKA UNIV,SCH MED,DEPT LAB MED,1-1-50 FUKUSHIMA,FUKUSHIMA KU,OSAKA 553,JAPAN

来源：

AUTOIMMUNITY | 1992年 / 11卷 / 04期

关键词：

NK ACTIVITY; NK CELLS; GRAVES DISEASE; HASHIMOTOS THYROIDITIS; POSTPARTUM THYROID DISEASE;

D O I：

10.3109/08916939209035161

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Changes in the activity and number of natural killer (NK) cells in peripheral blood in patients with autoimmune thyroid disease were examined. NK activity was measured in a 4-hr 51Cr-release assay and the number of NK cells was analyzed with FITC-conjugated monoclonal antibodies by use of an automated flow cytometer. NK activity in patients with untreated Graves' disease (n=25, 39.7+13.5% P<0.05) and Hashimoto's thyroiditis (n=18, 41.0±14.2% P<0.05) was high compared to the activity in non-pregnant controls (n=61, 32.6±15.0% NK activity in patients with postpartum Graves' thyrotoxicosis (n=11, 48.6±18.9% was markedly increased compared to the activity in non-pregnant controls (P<0.01) and in postpartum controls (n=29, 33.8±15.2% P<0.05), although the mean ages of each group did not differ significantly. Moreover, NK activities in the thyrotoxic state were significantly higher than those in the euthyroid state in the same patients with postpartum Graves' thyrotoxicosis or with postpartum destructive thyrotoxicosis. The number of CD16 positive cells increased in patients with postpartum Graves' thyrotoxicosis. However the number of CD 16 and CD57 positive cells were normal in all other groups of patients. These results indicate that an increase of NK activity is associated with exacerbation of autoimmune thyroid disease both in Hashimoto's thyroiditis and in Graves' disease and suggest that NK cells might have an important role for the control of disease activity in autoimmune thyroid disease. © 1992 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

引用

页码：239 / 246

页数：8

共 31 条

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