EFFECTS OF RHUEPO THERAPY ON EXERCISE CAPACITY IN HEMODIALYSIS-PATIENTS WITH CORONARY-ARTERY DISEASE

被引:16
作者
HASE, H
IMAMURA, Y
NAKAMURA, R
INISHI, Y
MACHII, K
YAMAGUCHI, T
机构
[1] Third Department of Internal Medicine, Toho University Ohashi Hospital, Tokyo, 2-17-6 Ohasi, Meguro-ku
来源
JAPANESE CIRCULATION JOURNAL-ENGLISH EDITION | 1993年 / 57卷 / 02期
关键词
RECOMBINANT HUMAN ERYTHROPOIETIN; CORONARY ARTERY DISEASE; TREADMILL EXERCISE TESTING; HEMODIALYSIS; EXERCISE-INDUCED ST DEPRESSION;
D O I
10.1253/jcj.57.131
中图分类号
N09 [自然科学史]; B [哲学、宗教];
学科分类号
01 ; 0101 ; 010108 ; 060207 ; 060305 ; 0712 ;
摘要
We investigated the effects of recombinant human erythropoietin (rHuEPO) therapy on exercise capacity by symptom-limited maximal treadmill exercise testing in 9 patients with coronary artery disease who were receiving maintenance hemodialysis. The initial hemoglobin concentration of 7.9 +/- 0.7 g/dl, (mean +/- S. D.) rose to 10.4 +/- 1.1 g/dl, (p<0.01) after three months of rHuEPO therapy. The partial correction of renal anemia resulted in a significant increase in exercise duration (from 278 +/- 84 sec to 384 +/- 74 sec, p<0.01) and maximum pressure-rate product (from 228.3 +/- 50.3 mmHg.bpm/10(2) to 262.8 +/- 40.4 mmHg.bpm/10(2), p<0.01). The maximum exercise-induced ST segment depression significantly decreased after treatment (from 1.3 +/- 0.5 mm to 0.5 +/- 0.5 mm, p<0.05). These results suggest that the improvement in maximum coronary oxygen supply exceeded the increased maximum myocardial oxygen requirements after the partial correction of renal anemia by rHuEPO therapy in hemodialysis patients with coronary artery disease.
引用
收藏
页码:131 / 137
页数:7
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