THE TIME COURSE OF CHANGES IN D1 AND D2 RECEPTOR-BINDING IN THE STRIATUM FOLLOWING A SELECTIVE LESION OF STRIATONIGRAL NEURONS

被引：18

作者：

HARRISON, MB ^{[1
]}

WILEY, RG ^{[1
]}

WOOTEN, GF ^{[1
]}

机构：

[1] DVAMC,NEUROL SERV 147,NASHVILLE,TN 37212

来源：

BRAIN RESEARCH | 1992年 / 596卷 / 1-2期

关键词：

DOPAMINE RECEPTOR; BASAL GANGLIA; SUICIDE TRANSPORT; QUANTITATIVE AUTORADIOGRAPHY; VOLKENSIN;

D O I：

10.1016/0006-8993(92)91567-X

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The suicide transport agent volkensin was used to produce a selective lesion of striatonigral projection neurons and the time course of changes in binding at striatal D1 and D2 receptors analyzed. Both show a time-dependent decrease with two-thirds of the total change occurring within the first 10 days and a greater decrease in D1 receptor density at all time points. Our results confirm selective localization of D1 receptors to striatonigral neurons and are consistent with localization of some striatal D2 receptors to striatonigral neurons.

引用

页码：330 / 336

页数：7

共 19 条

[1]

ALTAR CA, 1987, J NEUROSCI, V7, P213

[2] TOPOGRAPHY OF SUBSTANTIA-NIGRA INNERVATION BY D1 RECEPTOR-CONTAINING STRIATAL NEURONS [J].