ELIMINATION OF ELECTROCHEMICALLY-ACTIVE INTERFERENTS IN AMPEROMETRIC BIOSENSOR MEASUREMENTS - APPLICATION TO ONLINE MONITORING OF GLUCOSE AND GLUTAMATE

被引：30

作者：

KOSHY, A ^{[1
]}

ZILKHA, E ^{[1
]}

OBRENOVITCH, TP ^{[1
]}

BENNETTO, HP ^{[1
]}

RICHARDS, DA ^{[1
]}

SYMON, L ^{[1
]}

机构：

[1] KINGS COLL,BIOELECTROCHEM & BIOSENSORS GRP,LONDON W8 7AH,ENGLAND

来源：

ANALYTICAL LETTERS | 1993年 / 26卷 / 05期

关键词：

AMPEROMETRIC; BIOSENSOR; GLUCOSE; GLUCOSE OXIDASE; GLUTAMATE; GLUTAMATE OXIDASE; INTERFERENTS; ENZYME ELECTRODE;

D O I：

10.1080/00032719308019868

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A novel method of eliminating interferences which arise from electrochemically active substances is described. The sample solutions are passed through a platinum tube electrode inserted into the sample flow line, where they are subjected to DC pre-electrolysis before delivery to a detector cell containing an enzyme electrode. This method was specifically developed to avoid the interference of monoamines and ascorbic acid when brain extracellular fluid is analysed for glutamate, glucose or lactate using an amperometric enzyme flow-cell. HPLC analysis of the reaction products showed that the pre-oxidation treatment efficiently removes the principal interferents, but leaves unaffected the analyte of interest.

引用

页码：831 / 849

页数：19

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