TRANSPLANTED SUPRACHIASMATIC NUCLEUS DETERMINES CIRCADIAN PERIOD

被引：1381

作者：

RALPH, MR

FOSTER, RG

DAVIS, FC

MENAKER, M

机构：

[1] UNIV VIRGINIA,DEPT BIOL,CHARLOTTESVILLE,VA 22903

[2] NORTHEASTERN UNIV,DEPT BIOL,BOSTON,MA 02115

来源：

SCIENCE | 1990年 / 247卷 / 4945期

关键词：

D O I：

10.1126/science.2305266

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The pacemaker role of the suprachiasmatic nucleus in a mammalian circadian system was tested by neural transplantation by using a mutant strain of hamster that shows a short circadian period. Small neural grafts from the suprachiasmatic region restored circadian rhythms to arrhythmic animals whose own nucleus had been ablated. The restored rhythms always exhibited the period of the donor genotype regardless of the direction of the transplant or genotype of the host. The basic period of the overt circadian rhythm therefore is determined by cells of the suprachiasmatic region.

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页码：975 / 978

页数：4

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