YERSINIA ASSOCIATED ARTHRITIS IN SHR RATS - EFFECT OF THE MICROBIAL STATUS OF THE HOST

被引：23

作者：

GRIPENBERGLERCHE, C

TOIVANEN, P

机构：

[1] Dept. of Medical Microbiology, Turku University, SF-20520 Turku

来源：

ANNALS OF THE RHEUMATIC DISEASES | 1993年 / 52卷 / 03期

关键词：

D O I：

10.1136/ard.52.3.223

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Following the intravenous injection of live Yersinia enterocolitica O:8, 50-69% of SHR rats developed arthritis; these rats were antibody free against all rat pathogens tested. In contrast, only 20-25% of SHR rats which had serum antibodies against Bacillus piliformis, Kilham rat virus, and Toolan H-1 virus developed arthritis. The results indicate that the microbial load of the host has a profound effect on the susceptibility to experimental arthritis.

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页码：223 / 228

页数：6

相关论文

共 21 条

[1] A MYCOBACTERIAL 65-KD HEAT-SHOCK PROTEIN INDUCES ANTIGEN-SPECIFIC SUPPRESSION OF ADJUVANT ARTHRITIS, BUT IS NOT ITSELF ARTHRITOGENIC [J].

BILLINGHAM, MEJ ;

CARNEY, S ;

BUTLER, R ;

COLSTON, MJ .

JOURNAL OF EXPERIMENTAL MEDICINE, 1990, 171 (01) :339-344

[2] MEASUREMENT OF IMMUNOGLOBULIN-M, IMMUNOGLOBULIN-G, AND IMMUNOGLOBULIN-A ANTIBODIES AGAINST YERSINIA-ENTEROCOLITICA BY ENZYME-LINKED IMMUNOSORBENT-ASSAY - COMPARISON OF LIPOPOLYSACCHARIDE AND WHOLE BACTERIUM AS ANTIGEN [J].

GRANFORS, K ;

VILJANEN, MK ;

TOIVANEN, A .

JOURNAL OF CLINICAL MICROBIOLOGY, 1981, 14 (01) :6-14

[3] DEVELOPMENT OF AN EXPERIMENTAL ANIMAL-MODEL FOR REACTIVE ARTHRITIS INDUCED BY YERSINIA-ENTEROCOLITICA INFECTION [J].

HILL, JL ;

YU, DTY .

INFECTION AND IMMUNITY, 1987, 55 (03) :721-726

[4]

JEPPSSON JO, 1979, CLIN CHEM, V25, P629

[5]

KOCH AL, 1981, MANUAL METHODS GENER, P188

[6] SUSCEPTIBILITY TO ADJUVANT-INDUCED ARTHRITIS AMONG GERMFREE, SPECIFIC-PATHOGEN-FREE, AND CONVENTIONAL RATS [J].

KOHASHI, O ;

KUWATA, J ;

UMEHARA, K ;

UEMURA, F ;

TAKAHASHI, T ;

OZAWA, A .

INFECTION AND IMMUNITY, 1979, 26 (03) :791-794

[7] SUPPRESSIVE EFFECT OF ESCHERICHIA-COLI ON ADJUVANT-INDUCED ARTHRITIS IN GERM-FREE RATS [J].

KOHASHI, O ;

KOHASHI, Y ;

TAKAHASHI, T ;

OZAWA, A ;

SHIGEMATSU, N .

ARTHRITIS AND RHEUMATISM, 1986, 29 (04) :547-553

[8] CORRELATION OF AUTO-AGGLUTINATION AND VIRULENCE OF YERSINIAE [J].

LAIRD, WJ ;

CAVANAUGH, DC .

JOURNAL OF CLINICAL MICROBIOLOGY, 1980, 11 (04) :430-432

[9] LONG-TERM FOLLOW-UP OF SHR RATS WITH EXPERIMENTAL YERSINIA ASSOCIATED ARTHRITIS [J].

MERILAHTIPALO, R ;

GRIPENBERGLERCHE, C ;

SODERSTROM, KO ;

TOIVANEN, P .

ANNALS OF THE RHEUMATIC DISEASES, 1992, 51 (01) :91-96

[10]

SCHWIMMBECK PL, 1988, J IMMUNOL, V10, P3394