(R)-1-ACETYL-5-ISOPROPOXY-3-PYRROLIN-2-ONE - A VERSATILE CHIRAL DIENOPHILE FROM (S)-MALIC ACID

被引：60

作者：

KOOT, WJ ^{[1
]}

HIEMSTRA, H ^{[1
]}

SPECKAMP, WN ^{[1
]}

机构：

[1] UNIV AMSTERDAM,DEPT ORGAN CHEM,NIEUWE ACHTERGRACHT 129,1018 WS AMSTERDAM,NETHERLANDS

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1992年 / 57卷 / 04期

关键词：

D O I：

10.1021/jo00030a002

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The title compound, readily prepared from (S)-malic acid, reacts as a Diels-Alder dienophile with several 1,3-dienes with excellent regio- and stereoselectivity without loss of enantiomeric purity. The synthesis of an enantiomerically pure intermediate in a projected synthesis of gelsemine is detailed.

引用

页码：1059 / 1061

页数：3

共 25 条

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