COEXISTENCE OF CONGENITAL AFIBRINOGENEMIA AND PROTEIN-C DEFICIENCY IN A PATIENT

被引：19

作者：

HANANO, M

TAKAHASHI, H

ITOH, M

SHIBATA, A

机构：

[1] NIIGATA UNIV,DEPT INTERNAL MED 1,1-757 ASAHIMACHI,NIIGATA 951,JAPAN

[2] MUIKAMACHI PREFECTURAL HOSP,DIV INTERNAL MED,NIIGATA,JAPAN

来源：

AMERICAN JOURNAL OF HEMATOLOGY | 1992年 / 41卷 / 01期

关键词：

FIBRINOGEN; PROTEIN-C; BLOOD COAGULATION; ARTERIAL OCCLUSIVE DISEASE;

D O I：

10.1002/ajh.2830410111

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A rare association of congenital afibrinogenemia and hereditary protein C deficiency is described in a 37-year-old female who suffered from ischemic necrosis in the left first toe. The diagnosis of afibrinogenemia was assessed by the absence of fibrinogen in clotting and immunological assays. The diagnosis of hereditary heterozygous type I protein C deficiency was based on the evidence of proportional decreases of activity and antigen of plasma protein C in the propositus, her mother, and two maternal aunts.

引用

页码：57 / 60

页数：4

共 19 条

[1]

AWBREY BJ, 1979, J BIOL CHEM, V254, P4092

[2]

BIGGS R, 1976, HUMAN BLOOD COAGULAT, P657

[3] CONGENITAL PROTEIN-C DEFICIENCY AND VENOUS THROMBOEMBOLISM - A STUDY OF 3 DUTCH FAMILIES [J].