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BIOLOGICAL EFFECTS OF THE ANTIBIOTIC BREFELDIN-A (DECUMBIN, CYANEIN, ASCOTOXIN, SYNERGISIDIN) - A RETROSPECTIVE

被引：53
作者：
BETINA, V
机构：
来源：
FOLIA MICROBIOLOGICA | 1992年 / 37卷 / 01期
关键词：
D O I：
10.1007/BF02814572
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Brefeldin A has been recently characterized to act as an inhibitor of intracellular protein export with profound effects on the structure and function of the Golgi apparatus in animal cells. Manifold activities of the antibiotic (under different names) published in the 1960's and 1970's are reviewed: effects on fungal growth and morphogenesis, inhibition of mitosis in plant cells, cytotoxicity, cancerostatic, antiviral and antinematodal activity and peculiar effeCtS on DNA, RNA and protein synthesis in microbial and animal cells.
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页码：3 / 11
页数：9
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