POSTTRANSLATIONAL BACKBONE MODIFICATIONS IN THE RIBOSOMAL BIOSYNTHESIS OF THE GLYCINE-RICH ANTIBIOTIC MICROCIN-B17

被引：58

作者：

BAYER, A

FREUND, S

NICHOLSON, G

JUNG, G

机构：

[1] Institut für Organische Chemie, Universität Tübingen, D-72076

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH | 1993年 / 32卷 / 09期

关键词：

D O I：

10.1002/anie.199313361

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

2‐Aminomethylthiazol‐4‐carboxylic acid 1 is the result of one of a total of eight posttranslational backbone modifications in a very active gyrase inhibitor, microcin B 17. The structure of this highly modified 43‐peptide was elucidated through a combination of analytical and spectroscopic techniques, especially two‐dimensional NMR spectroscopy of a 15N‐labeled peptide. (Figure Presented.) Copyright © 1993 by VCH Verlagsgesellschaft mbH, Germany

引用

页码：1336 / 1339

页数：4

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