A NEW GRADIENT MATRIX - FORMULATION AND CHARACTERIZATION

被引：24

作者：

HILDGEN, P

MCMULLEN, JN

机构：

[1] Faculty of Pharmacy, University of Montreal, H3C 3J7 Quebec, CP6128, Suc A, Montreal

来源：

JOURNAL OF CONTROLLED RELEASE | 1995年 / 34卷 / 03期

关键词：

GRADIENT SYSTEM; CONTROLLED RELEASE; ZERO-ORDER; POLYMERIC MATRIX;

D O I：

10.1016/0168-3659(95)00014-Y

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A gradient matrix system for potential zero order release of drug is presented. The device consists of a cylinder composed of a hydrophobic polymer which is characterized by a concentration gradient along its length. The manufacturing process is described. It consists of controlled sedimentation by centrifugation in a melted polymer. The gradient is characterized by measuring concentration and particles distribution. The effects of the process parameters are studied. It is shown that the device can approximate a zero order kinetic of release.

引用

页码：263 / 271

页数：9

共 12 条

[1] DIFFUSIONAL RELEASE OF A SOLUTE FROM A POROUS POLYMERIC MATRIX [J].