GG167 (4-GUANIDINO-2,4-DIDEOXY-2,3-DEHYDRO-N-ACETYLNEURAMINIC ACID) IS A POTENT INHIBITOR OF INFLUENZA-VIRUS IN FERRETS

被引：80

作者：

RYAN, DM ^{[1
]}

TICEHURST, J ^{[1
]}

DEMPSEY, MH ^{[1
]}

机构：

[1] GLAXO WELLCOME RES & DEV LTD,STEVENAGE,HERTS,ENGLAND

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1995年 / 39卷 / 11期

基金：

英国惠康基金;

关键词：

D O I：

10.1128/AAC.39.11.2583

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

GG167 (4-guanidino-2,4-dideoxy-2,3-dehydro-N-acteylneuraminic acid) is a novel viral neuraminidase (sialidase) inhibitor which, following intranasal administration in ferrets, is at least 100 to 1,000 times more effective than ribavirin and amantadine against influenza A and B viruses. It retains its activity even when treatments are delayed until 24 h postinfection and has no effect on the serum antibody response to infection.

引用

页码：2583 / 2584

页数：2

共 5 条

[1]

EFTHYMIOPOULOS C, 1994, 34 INT C ANT AG CHEM, P265

[2] INHIBITION OF INFLUENZA-VIRUS REPLICATION IN MICE BY GG167 (4-GUANIDINO-2,4-DIDEOXY-2,3-DEHYDRO-N-ACETYLNEURAMINIC ACID) IS CONSISTENT WITH EXTRACELLULAR ACTIVITY OF VIRAL NEURAMINIDASE (SIALIDASE) [J].

RYAN, DM ;

TICEHURST, J ;

DEMPSEY, MH ;

PENN, CR .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1994, 38 (10) :2270-2275

[3] A virus obtained from influenza patients [J].

Smith, W ;

Andrewes, CH ;

Laidlaw, PP .

LANCET, 1933, 2 :66-68

[4] RATIONAL DESIGN OF POTENT SIALIDASE-BASED INHIBITORS OF INFLUENZA-VIRUS REPLICATION [J].

VONITZSTEIN, M ;

WU, WY ;

KOK, GB ;

PEGG, MS ;

DYASON, JC ;

JIN, B ;

PHAN, TV ;

SMYTHE, ML ;

WHITE, HF ;

OLIVER, SW ;

COLMAN, PM ;

VARGHESE, JN ;

RYAN, DM ;

WOODS, JM ;

BETHELL, RC ;

HOTHAM, VJ ;

CAMERON, JM ;

PENN, CR .

NATURE, 1993, 363 (6428) :418-423

[5] 4-GUANIDINO-2,4-DIDEOXY-2,3-DEHYDRO-N-ACETYLNEURAMINIC ACID IS A HIGHLY EFFECTIVE INHIBITOR BOTH OF THE SIALIDASE (NEURAMINIDASE) AND OF GROWTH OF A WIDE-RANGE OF INFLUENZA-A AND INFLUENZA-B VIRUSES IN-VITRO [J].

WOODS, JM ;

BETHELL, RC ;

COATES, JAV ;

HEALY, N ;

HISCOX, SA ;

PEARSON, BA ;

RYAN, DM ;

TICEHURST, J ;

TILLING, J ;

WALCOTT, SM ;

PENN, CR .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1993, 37 (07) :1473-1479

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