HIRUDIN IN HEMODIALYSIS

被引：26

作者：

BUCHA, E

MARKWARDT, F

NOWAK, G

机构：

[1] Institute of Pharmacology, Toxicology Medical Academy Erfurt, Erfurt

来源：

THROMBOSIS RESEARCH | 1990年 / 60卷 / 06期

关键词：

RECOMBINANT HIRUDIN; HEMODIALYSIS; PHARMACOKINETICS;

D O I：

10.1016/0049-3848(90)90229-6

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The usability of recombinant hirudin as anticoagulant agent in haemodialysis was studied in nephrectomized dogs. To this end, we examined the capability of recombinant hirudin to penetrate the membranes of different capillary dilyzers used. Furthermore we investigated the pharmacokinetic behaviour of recombinant hirudin in nephrectomized dogs as well as its capability to prevent the activation of the clotting system and fibrin deposition during haemodialysis. The present results evidence the efficiency of recombinant hirudin in preventing thrombus formation in experimental haemodialysis and hence its suitability as anticoagulant in such extracorporeal circulation.

引用

页码：445 / 455

页数：11

共 16 条

[1] HEPARIN-INDUCED THROMBOCYTOPENIA [J].

CHONG, BH ;

BERNDT, MC .

BLUT, 1989, 58 (02) :53-57

[2]

GLUSA E, 1990, HAEMOSTASIS, V20, P112

[3] On tests of blood-leaching in living creatures with the help of dialysis I Announcement [J].

Haas, G .

NAUNYN-SCHMIEDEBERGS ARCHIV FUR EXPERIMENTELLE PATHOLOGIE UND PHARMAKOLOGIE, 1926, 116 :158-172

[4]

HOFFMANN A, 1984, HAEMOSTASIS, V14, P164

[5] HEPARIN-INDUCED MOBILIZATION OF CALCIUM AND INORGANIC PHOSPHATE AND EXTRAOSSEOUS CALCIFICATION IN CHRONIC HEMODYALYSIS [J].

KORZ, R .

KLINISCHE WOCHENSCHRIFT, 1971, 49 (12) :684-&

[6] CLINICO-PHARMACOLOGICAL STUDIES WITH RECOMBINANT HIRUDIN [J].

MARKWARDT, F ;

NOWAK, G ;

STURZEBECHER, J ;

VOGEL, G .

THROMBOSIS RESEARCH, 1988, 52 (05) :393-400

[7]

MARKWARDT F, 1984, THROMB HAEMOSTASIS, V52, P160

[8]

MARKWARDT F, 1987, BIOMED BIOCHIM ACTA, V46, P237

[9]

MARKWARDT F, 1982, THROMB HAEMOSTASIS, V47, P226

[10]

MARKWARDT F, 1988, PHARMAZIE, V43, P202

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