CALPAIN INHIBITORS BLOCK TPA-DEPENDENT DOWN-REGULATION OF PROTEIN-KINASE-C

被引：12

作者：

ADACHI, Y ^{[1
]}

MURACHI, T ^{[1
]}

MAKI, M ^{[1
]}

ISHII, K ^{[1
]}

HATANAKA, M ^{[1
]}

机构：

[1] KYOTO UNIV,INST VIRUS RES,KYOTO 606,JAPAN

来源：

BIOMEDICAL RESEARCH-TOKYO | 1990年 / 11卷 / 05期

关键词：

D O I：

10.2220/biomedres.11.313

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

In vivo involvement of calpain in down-regulation of protein kinase C (PK-C) was studied in a neuroblastoma cell-line, BIM. Treatment ofBIM cells with l2-O-tetradecanoylphorbol 13-acetate (TPA) caused down-regulation of PK-C. Introduction of functional calpastatin peptide and inhibitors against calpain blocked TPAdependent down-regulation of PK-C, while a control peptide and the other inhibitors had no effect. The results suggest in vivo involvement of calpain in downregulation of PK-C during signal transduction. © 1990, Biomedical Research Press. All rights reserved.

引用

页码：313 / 317

页数：5

共 25 条

[1]

ADACHI Y, 1988, BIOL CHEM H-S, V369, P223

[2] CA-2+-DEPENDENT CYSTEINE PROTEINASE, CALPAIN-I AND CALPAIN-II ARE NOT PHOSPHORYLATED INVIVO [J].