ISONIAZID PROTECTS MICE AGAINST ENDOTOXIN LETHALITY WITHOUT INFLUENCING TUMOR-NECROSIS-FACTOR SYNTHESIS AND RELEASE

被引:12
作者
URBASCHEK, R
MANNEL, DN
URBANCZIK, R
机构
[1] FATOL ARZNEIMITTEL GMBH,RES & DEV GRP,W-6685 SCHIFFWEILER,GERMANY
[2] GERMAN CANC RES CTR,INST IMMUNOL & GENET,W-6900 HEIDELBERG 1,GERMANY
关键词
D O I
10.1128/AAC.35.8.1666
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Treatment of NMRI mice with isoniazid (INH; 25 mg/kg) intraperitoneally induced significant protection when it was injected before or after a lethal intravenous challenge with endotoxin. The INH preparation used was not contaminated with endotoxin. Tumor necrosis factor (TNF) was not elevated in sera from NMRI mice 2 h after the injection of INH. INH did not influence TNF synthesis or release determined in human monocytes in vitro. Therefore, it is concluded that the protective effect of INH against lethal endotoxin is not due to a suppressive effect of INH on TNF production.
引用
收藏
页码:1666 / 1668
页数:3
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