CHANGES IN CYTOKERATIN EXPRESSION IN GINGIVA DURING INFLAMMATION

被引：42

作者：

OUHAYOUN, JP

GOFFAUX, JC

SAWAF, MH

SHABANA, AHM

COLLIN, C

FOREST, N

机构：

[1] Laboratoire de Biologie-Odontologie, Universite Paris 7, Paris

来源：

JOURNAL OF PERIODONTAL RESEARCH | 1990年 / 25卷 / 05期

关键词：

D O I：

10.1111/j.1600-0765.1990.tb00917.x

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

Cytokeratins represent specific markers of certain pathways of epithelial differentiation. The purpose of this study was to describe the alterations of cytoker atin pattern and topographical distribution of individual cytokeratins in in flamed gingiva. Five healthy and 15 inflammatory samples of human gingiva were studied. From each biopsy, cryostat sections allowed histological staining, immunofluorescence microscopy using a battery of monoclonal antibodies to cytokeratins, and gel electrophoresis. The results show marked differences in cytokeratin expression by healthy epithelia as compared with inflamed gingiva: in susprabasal cell layers there were reductions or disappearance of cytokeratins 1, 2 and 10, 11 ‐ specific for terminal differentiation ‐ and increased expression of cytokeratins 4 and 13, as well as ‐ in basal and parabasal cell layers ‐expression of cytokeratin 19. These alterations might represent an adaptation of involved epithelia to the alterations brought about by the inflammatory process. Copyright © 1990, Wiley Blackwell. All rights reserved

引用

页码：283 / 292

页数：10

共 53 条

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