THE STRUCTURE OF POLYAMINE ANALOGS DETERMINES HEMOGLOBIN PRODUCTION AND CYTOTOXICITY IN MURINE ERYTHROLEUKEMIA-CELLS

被引:7
作者
CLEMENT, S
DELCROS, JG
BASU, HS
QUASH, G
MARTON, LJ
FEUERSTEIN, BG
机构
[1] FAC MED LYON SUD, INSERM, CJF 8905, IMMUNOCHIM LAB, F-69921 OULLINS, FRANCE
[2] UNIV CALIF SAN FRANCISCO, SCH MED, DEPT NEUROL SURG, BRAIN TUMOR RES CTR, SAN FRANCISCO, CA 94143 USA
[3] UNIV CALIF SAN FRANCISCO, SCH MED, DEPT HAEMATOL LAB, DIV MOLEC CYTOMETRY, SAN FRANCISCO, CA 94143 USA
[4] UNIV WISCONSIN, SCH MED, DEPT PATHOL & LAB MED, MADISON, WI 53706 USA
[5] UNIV WISCONSIN, SCH MED, DEPT ONCOL, MADISON, WI 53706 USA
[6] UNIV WISCONSIN, SCH MED, DEPT HUMAN ONCOL, MADISON, WI 53706 USA
关键词
D O I
10.1042/bj3090787
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The naturally occurring polyamine spermine induces haemoglobin synthesis in murine erythroleukaemia (MEL) cells. We have studied the ability of various polyamine analogues to inhibit cell growth and induce haemoglobin production. Polyamine analogues with free terminal amino groups were good inducers of haemoglobin production in MEL cells. Haemoglobin levels correlated with the number of positive charges: pentamines (five positive charges) were stronger inducers than tetramines (four positive charges). Compounds ethylated at their terminal amines were poor inducers of haemoglobin production but good inhibitors of MEL cell growth. These results provide evidence that polyamine analogues support specific biological functions of polyamines in MEL cells and suggest relationships between polyamine structure and function.
引用
收藏
页码:787 / 791
页数:5
相关论文
共 34 条
[1]   INVESTIGATIONS OF THE MECHANISM BY WHICH MAMMALIAN-CELL GROWTH IS INHIBITED BY N1N12-BIS(ETHYL)SPERMINE [J].
ALBANESE, L ;
BERGERON, RJ ;
PEGG, AE .
BIOCHEMICAL JOURNAL, 1993, 291 :131-137
[2]   TREATMENT WITH A POLYAMINE ANALOG ALTERS DNA-MATRIX ASSOCIATION IN HELA-CELL NUCLEI - A NUCLEOID HALO ASSAY [J].
BASU, HS ;
WRIGHT, WD ;
DEEN, DF ;
ROTIROTI, J ;
MARTON, LJ .
BIOCHEMISTRY, 1993, 32 (15) :4073-4076
[3]  
BASU HS, 1989, CANCER RES, V49, P5591
[4]   EFFECT OF POLYAMINE DEPLETION ON CHROMATIN STRUCTURE IN U-87 MG HUMAN BRAIN-TUMOR CELLS [J].
BASU, HS ;
STURKENBOOM, MCJM ;
DELCROS, JG ;
CSOKAN, PP ;
SZOLLOSI, J ;
FEUERSTEIN, BG ;
MARTON, LJ .
BIOCHEMICAL JOURNAL, 1992, 282 :723-727
[5]  
CANELLAKIS ZN, 1982, ADV POLYAMINE RES, V4, P769
[6]  
CELANO P, 1989, J BIOL CHEM, V264, P8922
[7]  
CELANO P, 1988, J BIOL CHEM, V263, P5491
[8]   MODULATION OF GROWTH GENE-EXPRESSION BY SELECTIVE ALTERATION OF POLYAMINES IN HUMAN-COLON CARCINOMA-CELLS [J].
CELANO, P ;
BERCHTOLD, CM ;
GIARDIELLO, FM ;
CASERO, RA .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1989, 165 (01) :384-390
[9]   DIFFERENTIAL-EFFECTS OF SPERMINE AND ITS ANALOGS ON THE STRUCTURES OF POLYNUCLEOTIDES COMPLEXED WITH ETHIDIUM-BROMIDE [J].
DELCROS, JG ;
STURKENBOOM, MCJM ;
BASU, HS ;
SHAFER, RH ;
SZOLLOSI, J ;
FEUERSTEIN, BG ;
MARTON, LJ .
BIOCHEMICAL JOURNAL, 1993, 291 :269-274
[10]   SPERMINE INDUCES HEMOGLOBIN-SYNTHESIS IN MURINE ERYTHROLEUKEMIA-CELLS [J].
DELCROS, JG ;
SCHWARTZ, B ;
CLEMENT, S ;
BASU, HS ;
MARTON, LJ ;
FEUERSTEIN, BG .
BIOCHEMICAL JOURNAL, 1995, 309 :781-786